Halofuginone hydrobromide
CAS No. 64924-67-0
Halofuginone hydrobromide ( Halofuginone HBr; Halofuginone-HBr )
产品货号. M18953 CAS No. 64924-67-0
Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth.
纯度: 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥356 | 有现货 |
|
5MG | ¥583 | 有现货 |
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10MG | ¥923 | 有现货 |
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25MG | ¥1863 | 有现货 |
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50MG | ¥2795 | 有现货 |
|
100MG | ¥4212 | 有现货 |
|
500MG | ¥8068 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Halofuginone hydrobromide
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth.
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产品描述Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. Halofuginone Hydrobromide is the hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibroproliferative diseases.
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同义词Halofuginone HBr; Halofuginone-HBr
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通路Others
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靶点Other Targets
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受体ProRS
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研究领域Neurological Disease
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适应症——
化学信息
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CAS Number64924-67-0
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分子量495.59
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分子式C16H17BrClN3O3 · HB
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纯度98%
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溶解度DMSO : 50 mg/mL 100.89 mM;
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SMILESC1C[C@H]([C@@H](NC1)CC(=O)Cn1cnc2cc(c(cc2c1=O)Cl)Br)O.Br
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化学全称(2R*,3S*)-7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4-3H-quinazolinone hydrobromide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Zhou H. et al. ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase. Nature. 2013 Feb 7;494(7435):121-4.
产品手册
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