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Halofuginone hydrobromide

CAS No. 64924-67-0

Halofuginone hydrobromide ( Halofuginone HBr; Halofuginone-HBr )

产品货号. M18953 CAS No. 64924-67-0

Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth.

纯度: 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥356 有现货
5MG ¥583 有现货
10MG ¥923 有现货
25MG ¥1863 有现货
50MG ¥2795 有现货
100MG ¥4212 有现货
500MG ¥8068 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Halofuginone hydrobromide
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth.
  • 产品描述
    Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. Halofuginone Hydrobromide is the hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibroproliferative diseases.
  • 同义词
    Halofuginone HBr; Halofuginone-HBr
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    ProRS
  • 研究领域
    Neurological Disease
  • 适应症
    ——

化学信息

  • CAS Number
    64924-67-0
  • 分子量
    495.59
  • 分子式
    C16H17BrClN3O3 · HB
  • 纯度
    98%
  • 溶解度
    DMSO : 50 mg/mL 100.89 mM;
  • SMILES
    C1C[C@H]([C@@H](NC1)CC(=O)Cn1cnc2cc(c(cc2c1=O)Cl)Br)O.Br
  • 化学全称
    (2R*,3S*)-7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4-3H-quinazolinone hydrobromide

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Zhou H. et al. ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase. Nature. 2013 Feb 7;494(7435):121-4.
产品手册
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